An experimental inhaled RNA medicine successfully reduced a selected inflammatory protein inside the lungs in an early human trial, suggesting that gene-silencing medicines may eventually be delivered directly to lung tissue.
A randomized study found major pain relief and improved sensation in people with severe painful diabetic neuropathy treated with high-frequency spinal-cord stimulation, while preliminary tissue findings raised questions about whether nerve changes may extend beyond pain control.
A randomized trial involving nearly 1,700 people found no statistically significant reduction in COPD exacerbations, cardiovascular events or death when metoprolol was added in patients who had no cardiovascular indication for the drug.
An AI system analysing ordinary carotid ultrasound images identified potentially vulnerable artery plaques and separated people into groups with substantially different subsequent stroke-related risk.
FDA has approved a treatment strategy that uses tumour DNA found in blood to detect drug resistance and change therapy before ordinary scans show that the cancer is worsening.
Zilganersen is the first approved treatment for Alexander disease and is designed to reduce production of the abnormal protein that drives this rare neurological disorder.
A genetically modified pig kidney worked for 271 days in a man with kidney failure, allowing him to avoid dialysis before he later received a human donor kidney.
The US FDA has strengthened the warning for ferric carboxymaltose after continued reports of serious low phosphate levels, particularly in people receiving repeated treatment.
An experimental immune-targeting treatment reduced intestinal damage during six weeks of gluten exposure in a small randomized study of adults with celiac disease.
A randomized trial in 360 people with severe tricuspid valve leakage found much better outcomes when a catheter-based repair was added to medical treatment.
